Assay Detail
Functional
CHEMBL718158
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Inhibition of anchorage independent growth of H-Ras transformed Rat-1 cells.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Rat1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Discovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.97 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359140 | — | — | 1 | 6.96 |
| CHEMBL430778 | — | — | 1 | 6.80 |
| CHEMBL355971 | — | — | 1 | 6.70 |
| CHEMBL148870 | — | — | 1 | 6.70 |
| CHEMBL358056 | — | — | 1 | 6.52 |
| CHEMBL148487 | — | — | 1 | 6.47 |
| CHEMBL358499 | — | — | 1 | 6.26 |
| CHEMBL151497 | — | — | 1 | 6.16 |
| CHEMBL348452 | — | — | 1 | 6.05 |
| CHEMBL359092 | — | — | 1 | 6.00 |
| CHEMBL149923 | — | — | 1 | 5.80 |
| CHEMBL341861 | — | — | 1 | 5.80 |
| CHEMBL147502 | — | — | 1 | 5.62 |
| CHEMBL150737 | — | — | 1 | 5.62 |
| CHEMBL151813 | — | — | 1 | 5.52 |
| CHEMBL356905 | — | — | 1 | 5.40 |
| CHEMBL358680 | — | — | 1 | 5.22 |
| CHEMBL151633 | — | — | 1 | 4.96 |
| CHEMBL151978 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359140 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL430778 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL355971 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL148870 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL358056 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL148487 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL358499 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL151497 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL348452 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL359092 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL149923 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL341861 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL147502 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL150737 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL151813 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL356905 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL358680 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL151633 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL151978 | — | EC50 | = | 12000.0 | nM | 4.92 |