Assay Detail
Binding
CHEMBL718311
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Inhibition of matrix metalloprotease-2 (MMP-2).
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Protease inhibitors: current status and future prospects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.96 | 10.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 10.08 |
| CHEMBL440498 | CTS-1027 | 2.0 | 1 | 9.66 |
| CHEMBL114116 | — | — | 1 | 8.00 |
| CHEMBL261932 | TANOMASTAT | 2.0 | 1 | 7.96 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.70 |
| CHEMBL115653 | CIPEMASTAT | 2.0 | 1 | 6.81 |
| CHEMBL114673 | — | — | 1 | 5.52 |
| CHEMBL23725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | Ki | = | 0.083 | nM | 10.08 |
| CHEMBL440498 | CTS-1027 | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL114116 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL261932 | TANOMASTAT | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL514138 | CGS-27023A | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL115653 | CIPEMASTAT | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL114673 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL23725 | — | Ki | < | 3.0 | nM | - |