Assay Detail
Binding
CHEMBL718312
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of matrix metalloprotease-2
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.96 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91636 | — | — | 1 | 8.96 |
| CHEMBL88520 | — | — | 1 | 8.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91636 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL88520 | — | Ki | = | 1.1 | nM | 8.96 |