Assay Detail
Binding
CHEMBL718390
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In vitro inhibitory activity against the catalytic domain of human matrix metalloprotease-14
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.42 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111257 | — | — | 1 | 7.00 |
| CHEMBL109806 | — | — | 1 | 6.82 |
| CHEMBL111179 | — | — | 1 | 6.72 |
| CHEMBL109861 | — | — | 1 | 6.60 |
| CHEMBL321213 | — | — | 1 | 6.54 |
| CHEMBL109214 | — | — | 1 | 6.54 |
| CHEMBL111678 | — | — | 1 | 6.50 |
| CHEMBL109655 | — | — | 1 | 6.42 |
| CHEMBL322795 | — | — | 1 | 6.41 |
| CHEMBL109579 | — | — | 1 | 6.36 |
| CHEMBL109770 | — | — | 1 | 6.24 |
| CHEMBL419750 | — | — | 1 | 6.23 |
| CHEMBL422251 | — | — | 1 | 6.23 |
| CHEMBL109603 | — | — | 1 | 6.13 |
| CHEMBL108494 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111257 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL109806 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL111179 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL109861 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL321213 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL109214 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL111678 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL109655 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL322795 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL109579 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL109770 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL419750 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL422251 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL109603 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL108494 | — | Ki | = | 3070.0 | nM | 5.51 |