Assay Detail
Binding
CHEMBL718391
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In vitro inhibitory activity against the ectodomain of the human matrix metalloprotease-14
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.63 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109806 | — | — | 1 | 6.96 |
| CHEMBL109214 | — | — | 1 | 6.82 |
| CHEMBL110970 | — | — | 1 | 6.75 |
| CHEMBL111179 | — | — | 1 | 6.75 |
| CHEMBL111678 | — | — | 1 | 6.70 |
| CHEMBL111257 | — | — | 1 | 6.68 |
| CHEMBL109353 | — | — | 1 | 6.68 |
| CHEMBL322795 | — | — | 1 | 6.48 |
| CHEMBL422251 | — | — | 1 | 6.48 |
| CHEMBL109770 | — | — | 1 | 6.41 |
| CHEMBL111450 | — | — | 1 | 6.40 |
| CHEMBL422250 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109806 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL109214 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL110970 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL111179 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL111678 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL111257 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL109353 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL322795 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL422251 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL109770 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL111450 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL422250 | — | Ki | = | 400.0 | nM | 6.40 |