Assay Detail
Binding
CHEMBL718393
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Inhibition of matrix metalloprotease-14
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.74 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109353 | — | — | 1 | 7.30 |
| CHEMBL110970 | — | — | 1 | 6.70 |
| CHEMBL111450 | — | — | 1 | 6.62 |
| CHEMBL422250 | — | — | 1 | 6.62 |
| CHEMBL110750 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109353 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL110970 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL111450 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL422250 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL110750 | — | Ki | = | 340.0 | nM | 6.47 |