Assay Detail
Binding
CHEMBL718397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of matrix metalloprotease-14 (MMP-14)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.47 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 7.64 |
| CHEMBL358539 | — | — | 1 | 7.47 |
| CHEMBL147881 | — | — | 1 | 7.41 |
| CHEMBL147882 | — | — | 1 | 7.28 |
| CHEMBL146718 | — | — | 1 | 7.21 |
| CHEMBL148214 | — | — | 1 | 7.17 |
| CHEMBL147489 | — | — | 1 | 6.28 |
| CHEMBL148406 | — | — | 1 | 6.08 |
| CHEMBL148171 | — | — | 1 | 6.06 |
| CHEMBL146289 | — | — | 1 | 5.96 |
| CHEMBL356124 | — | — | 1 | 5.51 |
| CHEMBL424130 | — | — | 1 | 5.34 |
| CHEMBL147604 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL358539 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL147881 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL147882 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL146718 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL148214 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL147489 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL148406 | — | IC50 | = | 835.0 | nM | 6.08 |
| CHEMBL148171 | — | IC50 | = | 867.0 | nM | 6.06 |
| CHEMBL146289 | — | IC50 | = | 1102.0 | nM | 5.96 |
| CHEMBL356124 | — | IC50 | = | 3108.0 | nM | 5.51 |
| CHEMBL424130 | — | IC50 | = | 4613.0 | nM | 5.34 |
| CHEMBL147604 | — | IC50 | = | 20820.0 | nM | 4.68 |