Assay Detail
Binding
CHEMBL718401
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Inhibition of matrix metalloprotease-15 (MMP-15)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.10 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358539 | — | — | 1 | 8.40 |
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 8.22 |
| CHEMBL148214 | — | — | 1 | 8.22 |
| CHEMBL147881 | — | — | 1 | 7.77 |
| CHEMBL147882 | — | — | 1 | 7.72 |
| CHEMBL148171 | — | — | 1 | 7.54 |
| CHEMBL146718 | — | — | 1 | 7.36 |
| CHEMBL147489 | — | — | 1 | 6.90 |
| CHEMBL146289 | — | — | 1 | 6.66 |
| CHEMBL148406 | — | — | 1 | 6.42 |
| CHEMBL356124 | — | — | 1 | 6.21 |
| CHEMBL424130 | — | — | 1 | 5.75 |
| CHEMBL147604 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358539 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL19611 | ILOMASTAT | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL148214 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL147881 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL147882 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL148171 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL146718 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL147489 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL146289 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL148406 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL356124 | — | IC50 | = | 621.0 | nM | 6.21 |
| CHEMBL424130 | — | IC50 | = | 1789.0 | nM | 5.75 |
| CHEMBL147604 | — | IC50 | = | 7303.0 | nM | 5.14 |