Assay Detail
Binding
CHEMBL718404
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Inhibition of matrix metalloprotease-16
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.70 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325163 | — | — | 1 | 5.70 |
| CHEMBL431680 | — | — | 1 | - |
| CHEMBL115263 | — | — | 1 | - |
| CHEMBL114878 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325163 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL431680 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL115263 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL114878 | — | Ki | > | 2000.0 | nM | - |