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Assay Detail

CHEMBL718405

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of matrix metalloprotease-16 (MMP-16)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Matrix metalloproteinase-16 (CHEMBL2200)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors.
Ma D, Wu W, Yang G, Li J, Li J, Ye Q.
Bioorg Med Chem Lett (2004) 14 : 47 -50
PubMed 14684295 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.95 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL19611 ILOMASTAT 2.0 1 8.10
CHEMBL148214 1 7.80
CHEMBL147882 1 7.68
CHEMBL358539 1 7.66
CHEMBL147881 1 7.46
CHEMBL148171 1 7.40
CHEMBL146718 1 7.25
CHEMBL147489 1 6.75
CHEMBL146289 1 6.74
CHEMBL148406 1 6.70
CHEMBL356124 1 5.78
CHEMBL424130 1 5.74
CHEMBL147604 1 5.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL19611 ILOMASTAT IC50 = 8.0 nM 8.10
CHEMBL148214 IC50 = 16.0 nM 7.80
CHEMBL147882 IC50 = 21.0 nM 7.68
CHEMBL358539 IC50 = 22.0 nM 7.66
CHEMBL147881 IC50 = 35.0 nM 7.46
CHEMBL148171 IC50 = 40.0 nM 7.40
CHEMBL146718 IC50 = 56.0 nM 7.25
CHEMBL147489 IC50 = 177.0 nM 6.75
CHEMBL146289 IC50 = 184.0 nM 6.74
CHEMBL148406 IC50 = 202.0 nM 6.70
CHEMBL356124 IC50 = 1677.0 nM 5.78
CHEMBL424130 IC50 = 1839.0 nM 5.74
CHEMBL147604 IC50 = 4633.0 nM 5.33