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Assay Detail

CHEMBL718406

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of matrix metalloprotease-17
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Matrix metalloproteinase-17 (CHEMBL2937)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Reverse hydroxamate-based selective TACE inhibitors.
Kamei N, Tanaka T, Kawai K, Miyawaki K, Okuyama A, Murakami Y, Arakawa Y, Haino M, Harada T, Shimano M.
Bioorg Med Chem Lett (2004) 14 : 2897 -2900
PubMed 15125955 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.00 6.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL431226 1 6.66
CHEMBL329967 1 6.48
CHEMBL99365 1 6.46
CHEMBL98390 1 6.46
CHEMBL328645 1 6.30
CHEMBL95414 1 6.26
CHEMBL319782 1 6.22
CHEMBL419896 1 5.96
CHEMBL328199 1 5.70
CHEMBL98852 1 5.60
CHEMBL99045 1 5.52
CHEMBL99995 1 5.52
CHEMBL318252 1 5.40
CHEMBL98202 1 5.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL431226 IC50 = 220.0 nM 6.66
CHEMBL329967 IC50 = 330.0 nM 6.48
CHEMBL99365 IC50 = 350.0 nM 6.46
CHEMBL98390 IC50 = 350.0 nM 6.46
CHEMBL328645 IC50 = 500.0 nM 6.30
CHEMBL95414 IC50 = 550.0 nM 6.26
CHEMBL319782 IC50 = 600.0 nM 6.22
CHEMBL419896 IC50 = 1100.0 nM 5.96
CHEMBL328199 IC50 = 2000.0 nM 5.70
CHEMBL98852 IC50 = 2500.0 nM 5.60
CHEMBL99045 IC50 = 3000.0 nM 5.52
CHEMBL99995 IC50 = 3000.0 nM 5.52
CHEMBL318252 IC50 = 4000.0 nM 5.40
CHEMBL98202 IC50 = 4000.0 nM 5.40