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Assay Detail

CHEMBL718925

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against the Matrix Metalloprotease 2 (MMP-2)
ChEMBL ↗
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

72 kDa type IV collagenase (CHEMBL333) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties.
Scozzafava A, Supuran CT.
J Med Chem (2000) 43 : 1858 -1865
PubMed 10794702 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 68 8.12 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL293357 — — 1 9.22
CHEMBL439931 — — 1 9.22
CHEMBL293503 — — 1 9.15
CHEMBL293528 — — 1 9.15
CHEMBL54483 — — 1 9.10
CHEMBL54904 — — 1 9.05
CHEMBL54054 — — 1 8.96
CHEMBL56498 — — 1 8.92
CHEMBL55522 — — 1 8.82
CHEMBL55110 — — 1 8.82
CHEMBL55521 — — 1 8.80
CHEMBL55984 — — 1 8.74
CHEMBL54535 — — 1 8.70
CHEMBL53847 — — 1 8.60
CHEMBL54436 — — 1 8.60
CHEMBL301085 — — 1 8.55
CHEMBL300807 — — 1 8.52
CHEMBL300362 — — 1 8.52
CHEMBL56025 — — 1 8.52
CHEMBL301977 — — 1 8.30
CHEMBL54621 — — 1 8.30
CHEMBL54915 — — 1 8.22
CHEMBL52531 — — 1 8.22
CHEMBL54965 — — 1 8.15
CHEMBL299600 — — 1 8.15
CHEMBL54697 — — 1 8.10
CHEMBL297488 — — 1 8.10
CHEMBL56065 — — 1 8.05
CHEMBL298606 — — 1 8.05
CHEMBL292431 — — 1 8.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL293357 — Ki = 0.6 nM 9.22
CHEMBL439931 — Ki = 0.6 nM 9.22
CHEMBL293528 — Ki = 0.7 nM 9.15
CHEMBL293503 — Ki = 0.7 nM 9.15
CHEMBL54483 — Ki = 0.8 nM 9.10
CHEMBL54904 — Ki = 0.9 nM 9.05
CHEMBL54054 — Ki = 1.1 nM 8.96
CHEMBL56498 — Ki = 1.2 nM 8.92
CHEMBL55522 — Ki = 1.5 nM 8.82
CHEMBL55110 — Ki = 1.5 nM 8.82
CHEMBL55521 — Ki = 1.6 nM 8.80
CHEMBL55984 — Ki = 1.8 nM 8.74
CHEMBL54535 — Ki = 2.0 nM 8.70
CHEMBL54436 — Ki = 2.5 nM 8.60
CHEMBL53847 — Ki = 2.5 nM 8.60
CHEMBL301085 — Ki = 2.8 nM 8.55
CHEMBL300807 — Ki = 3.0 nM 8.52
CHEMBL300362 — Ki = 3.0 nM 8.52
CHEMBL56025 — Ki = 3.0 nM 8.52
CHEMBL301977 — Ki = 5.0 nM 8.30
CHEMBL54621 — Ki = 5.0 nM 8.30
CHEMBL54915 — Ki = 6.0 nM 8.22
CHEMBL52531 — Ki = 6.0 nM 8.22
CHEMBL54965 — Ki = 7.0 nM 8.15
CHEMBL299600 — Ki = 7.0 nM 8.15
CHEMBL54697 — Ki = 8.0 nM 8.10
CHEMBL297488 — Ki = 8.0 nM 8.10
CHEMBL56065 — Ki = 9.0 nM 8.05
CHEMBL298606 — Ki = 9.0 nM 8.05
CHEMBL292431 — Ki = 10.0 nM 8.00
CHEMBL301786 — Ki = 10.0 nM 8.00
CHEMBL55154 — Ki = 10.0 nM 8.00
CHEMBL293305 — Ki = 10.0 nM 8.00
CHEMBL280017 — Ki = 11.0 nM 7.96
CHEMBL53051 — Ki = 12.0 nM 7.92
CHEMBL53044 — Ki = 12.0 nM 7.92
CHEMBL299023 — Ki = 12.0 nM 7.92
CHEMBL298822 — Ki = 13.0 nM 7.89
CHEMBL56951 — Ki = 13.0 nM 7.89
CHEMBL54617 — Ki = 13.0 nM 7.89
CHEMBL417200 — Ki = 13.0 nM 7.89
CHEMBL301177 — Ki = 15.0 nM 7.82
CHEMBL51862 — Ki = 15.0 nM 7.82
CHEMBL53094 — Ki = 15.0 nM 7.82
CHEMBL55744 — Ki = 15.0 nM 7.82
CHEMBL53457 — Ki = 15.0 nM 7.82
CHEMBL417757 — Ki = 16.0 nM 7.80
CHEMBL55907 — Ki = 17.0 nM 7.77
CHEMBL53091 — Ki = 18.0 nM 7.75
CHEMBL53116 — Ki = 18.0 nM 7.75