Assay Detail
Binding
CHEMBL718938
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Inhibitory activity against Matrix metalloprotease-2 (concentration required for 50% inhibition of enzyme activity)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Homology modeling of gelatinase catalytic domains and docking simulations of novel sulfonamide inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.91 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296327 | — | — | 1 | 9.19 |
| CHEMBL47971 | — | — | 1 | 8.82 |
| CHEMBL297792 | S-3304 | 1.0 | 1 | 8.77 |
| CHEMBL49499 | — | — | 1 | 8.41 |
| CHEMBL48368 | — | — | 1 | 8.36 |
| CHEMBL50437 | — | — | 1 | 8.36 |
| CHEMBL295861 | — | — | 1 | 8.33 |
| CHEMBL49413 | — | — | 1 | 8.32 |
| CHEMBL50445 | — | — | 1 | 8.27 |
| CHEMBL298699 | — | — | 1 | 8.23 |
| CHEMBL296817 | — | — | 1 | 8.00 |
| CHEMBL291213 | — | — | 1 | 7.75 |
| CHEMBL49186 | — | — | 1 | 7.70 |
| CHEMBL297793 | — | — | 1 | 7.48 |
| CHEMBL45906 | — | — | 1 | 7.09 |
| CHEMBL291194 | — | — | 1 | 6.30 |
| CHEMBL49185 | — | — | 1 | 5.15 |
| CHEMBL298327 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296327 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL47971 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL297792 | S-3304 | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL49499 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL48368 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL50437 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL295861 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL49413 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL50445 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL298699 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL296817 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL291213 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL49186 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL297793 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL45906 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL291194 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL49185 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL298327 | — | IC50 | > | 20000.0 | nM | - |