Assay Detail
Binding
CHEMBL719130
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In Vitro inhibitory activity against the catalytic domain of the matrix metalloprotease-12
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.52 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109214 | — | — | 1 | 7.05 |
| CHEMBL109655 | — | — | 1 | 6.96 |
| CHEMBL109806 | — | — | 1 | 6.70 |
| CHEMBL111678 | — | — | 1 | 6.62 |
| CHEMBL109579 | — | — | 1 | 6.55 |
| CHEMBL321213 | — | — | 1 | 6.55 |
| CHEMBL109770 | — | — | 1 | 6.52 |
| CHEMBL109353 | — | — | 1 | 6.50 |
| CHEMBL419750 | — | — | 1 | 6.47 |
| CHEMBL110970 | — | — | 1 | 6.47 |
| CHEMBL322795 | — | — | 1 | 6.46 |
| CHEMBL422251 | — | — | 1 | 6.46 |
| CHEMBL109861 | — | — | 1 | 6.44 |
| CHEMBL111450 | — | — | 1 | 6.44 |
| CHEMBL422250 | — | — | 1 | 6.43 |
| CHEMBL109603 | — | — | 1 | 6.42 |
| CHEMBL108494 | — | — | 1 | 6.39 |
| CHEMBL110750 | — | — | 1 | 6.36 |
| CHEMBL111179 | — | — | 1 | 6.32 |
| CHEMBL111257 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109214 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL109655 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL109806 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL111678 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL109579 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL321213 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL109770 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL109353 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL419750 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL110970 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL322795 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL422251 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL109861 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL111450 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL422250 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL109603 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL108494 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL110750 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL111179 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL111257 | — | Ki | = | 520.0 | nM | 6.28 |