Assay Detail
Binding
CHEMBL719135
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Inhibition of human matrix metalloprotease-13 at pH 7.4
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.69 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10431 | — | — | 1 | 6.94 |
| CHEMBL10590 | — | — | 1 | 6.84 |
| CHEMBL274174 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10431 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL10590 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL274174 | — | IC50 | = | 498.0 | nM | 6.30 |