Assay Detail
Binding
CHEMBL719150
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Inhibitory activity against human matrix metalloprotease-13 in quenched fluorescence assay at pH 7.4
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.68 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276016 | — | — | 1 | 7.85 |
| CHEMBL10671 | — | — | 1 | 7.80 |
| CHEMBL10454 | — | — | 1 | 7.68 |
| CHEMBL10953 | — | — | 1 | 7.66 |
| CHEMBL10655 | — | — | 1 | 7.62 |
| CHEMBL10674 | — | — | 1 | 7.48 |
| CHEMBL10672 | — | — | 1 | 7.48 |
| CHEMBL10257 | — | — | 1 | 7.46 |
| CHEMBL275130 | — | — | 1 | 7.30 |
| CHEMBL11188 | — | — | 1 | 7.23 |
| CHEMBL274881 | — | — | 1 | 7.12 |
| CHEMBL10935 | — | — | 1 | 7.09 |
| CHEMBL10266 | — | — | 1 | 7.06 |
| CHEMBL10180 | — | — | 1 | 7.05 |
| CHEMBL10335 | — | — | 1 | 6.99 |
| CHEMBL10881 | — | — | 1 | 6.98 |
| CHEMBL10673 | — | — | 1 | 6.90 |
| CHEMBL10809 | — | — | 1 | 6.83 |
| CHEMBL10908 | — | — | 1 | 6.81 |
| CHEMBL275700 | — | — | 1 | 6.65 |
| CHEMBL10469 | — | — | 1 | 6.64 |
| CHEMBL10952 | — | — | 1 | 6.59 |
| CHEMBL10761 | — | — | 1 | 6.57 |
| CHEMBL10792 | — | — | 1 | 6.52 |
| CHEMBL10296 | — | — | 1 | 6.46 |
| CHEMBL10806 | — | — | 1 | 6.32 |
| CHEMBL10848 | — | — | 1 | 6.31 |
| CHEMBL10851 | — | — | 1 | 6.11 |
| CHEMBL11005 | — | — | 1 | 6.06 |
| CHEMBL10646 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276016 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL10671 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL10454 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL10953 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL10655 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL10674 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL10672 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL10257 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL275130 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL11188 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL274881 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL10935 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL10266 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL10180 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL10335 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL10881 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL10673 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL10809 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL10908 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL275700 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL10469 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL10952 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL10761 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL10792 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL10296 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL10806 | — | IC50 | = | 478.0 | nM | 6.32 |
| CHEMBL10848 | — | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL10851 | — | IC50 | = | 774.0 | nM | 6.11 |
| CHEMBL11005 | — | IC50 | = | 869.0 | nM | 6.06 |
| CHEMBL10646 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL10492 | — | IC50 | = | 1691.0 | nM | 5.77 |
| CHEMBL407640 | — | IC50 | = | 2037.0 | nM | 5.69 |
| CHEMBL10760 | — | IC50 | = | 2146.0 | nM | 5.67 |
| CHEMBL10822 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL275345 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL275754 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL268050 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL274997 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10193 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL417977 | — | IC50 | > | 1600.0 | nM | - |
| CHEMBL10885 | — | IC50 | > | 10000.0 | nM | - |