Assay Detail
Functional
CHEMBL728391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration was evaluated for its ability to inhibit microtubule assembly and protein polymerization by 50%
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural requirements for the binding of colchicine analogs to tubulin: the role of the C-10 substituent
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.15 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357889 | — | — | 1 | 5.72 |
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 5.60 |
| CHEMBL88059 | — | — | 1 | 5.58 |
| CHEMBL145740 | — | — | 1 | 5.57 |
| CHEMBL79720 | — | — | 1 | 5.42 |
| CHEMBL357199 | — | — | 1 | 5.37 |
| CHEMBL145125 | — | — | 1 | 5.24 |
| CHEMBL357071 | — | — | 1 | 5.16 |
| CHEMBL142588 | COLCHICEINE | — | 1 | 4.70 |
| CHEMBL145616 | — | — | 1 | 4.66 |
| CHEMBL142042 | — | — | 1 | 4.47 |
| CHEMBL344998 | — | — | 1 | 4.26 |
| CHEMBL347732 | — | — | 1 | - |
| CHEMBL356735 | — | — | 1 | - |
| CHEMBL356736 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357889 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL88059 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL145740 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL79720 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL357199 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL145125 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL357071 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL142588 | COLCHICEINE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL145616 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL142042 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL344998 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL347732 | — | IC50 | ~ | 500000.0 | nM | - |
| CHEMBL356735 | — | IC50 | = | 625000.0 | nM | - |
| CHEMBL356736 | — | IC50 | ~ | 200000.0 | nM | - |