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Assay Detail

CHEMBL728557

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Binding
Binding affinity towards aldosterone receptor (Mineralocorticoid receptor)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Kym PR, Kort ME, Coghlan MJ, Moore JL, Tang R, Ratajczyk JD, Larson DP, Elmore SW, Pratt JK, Stashko MA, Falls HD, Lin CW, Nakane M, Miller L, Tyree CM, Miner JN, Jacobson PB, Wilcox DM, Nguyen P, Lane BC.
J Med Chem (2003) 46 : 1016 -1030
PubMed 12620078 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 6.88 7.45

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267231 1 7.45
CHEMBL131 PREDNISOLONE 4.0 1 7.43
CHEMBL266282 AL-43 1 7.34
CHEMBL267940 1 7.24
CHEMBL8394 1 7.03
CHEMBL440454 1 6.60
CHEMBL268239 1 6.54
CHEMBL7671 1 6.46
CHEMBL266709 1 5.86
CHEMBL8209 1 -
CHEMBL8639 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267231 Ki = 35.8 nM 7.45
CHEMBL131 PREDNISOLONE Ki = 37.0 nM 7.43
CHEMBL266282 AL-43 Ki = 46.0 nM 7.34
CHEMBL267940 Ki = 57.0 nM 7.24
CHEMBL8394 Ki = 93.8 nM 7.03
CHEMBL440454 Ki = 251.0 nM 6.60
CHEMBL268239 Ki = 292.0 nM 6.54
CHEMBL7671 Ki = 350.0 nM 6.46
CHEMBL266709 Ki = 1370.0 nM 5.86
CHEMBL8209 Ki > 5000.0 nM -
CHEMBL8639 Ki > 5000.0 nM -