Assay Detail
Functional
CHEMBL728561
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mink |
| Cell Type | lung |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.76 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341280 | — | — | 1 | 8.54 |
| CHEMBL129677 | — | — | 1 | 8.54 |
| CHEMBL129153 | — | — | 1 | 7.62 |
| CHEMBL118928 | — | — | 1 | 7.36 |
| CHEMBL261454 | — | — | 1 | 7.33 |
| CHEMBL129760 | — | — | 1 | 7.33 |
| CHEMBL340203 | — | — | 1 | 7.03 |
| CHEMBL338196 | — | — | 1 | 7.03 |
| CHEMBL125846 | — | — | 1 | 6.86 |
| CHEMBL129678 | — | — | 1 | 6.45 |
| CHEMBL126180 | — | — | 1 | 6.40 |
| CHEMBL125738 | — | — | 1 | 6.26 |
| CHEMBL338713 | — | — | 1 | 6.17 |
| CHEMBL126789 | — | — | 1 | 6.10 |
| CHEMBL126676 | — | — | 1 | 5.92 |
| CHEMBL130025 | — | — | 1 | 5.78 |
| CHEMBL129553 | — | — | 1 | 5.47 |
| CHEMBL337978 | — | — | 1 | 5.45 |
| CHEMBL341534 | — | — | 1 | - |
| CHEMBL129280 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341280 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL129677 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL129153 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL118928 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL261454 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL129760 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL340203 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL338196 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL125846 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL129678 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL126180 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL125738 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL338713 | — | IC50 | = | 683.0 | nM | 6.17 |
| CHEMBL126789 | — | IC50 | = | 788.0 | nM | 6.10 |
| CHEMBL126676 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL130025 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL129553 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL337978 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL341534 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL129280 | — | IC50 | > | 9000.0 | nM | - |