Assay Detail
Functional
CHEMBL729160
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Antagonistic activity was determined in Human mineralocorticoid receptor(hMR) of CV-1 cells in cotransfection assay.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.09 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 7.85 |
| CHEMBL101914 | — | — | 1 | 6.45 |
| CHEMBL320690 | — | — | 1 | 6.13 |
| CHEMBL103232 | — | — | 1 | 6.01 |
| CHEMBL103092 | — | — | 1 | 6.00 |
| CHEMBL317921 | — | — | 1 | 5.97 |
| CHEMBL430855 | — | — | 1 | 5.97 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 5.92 |
| CHEMBL102754 | — | — | 1 | 5.87 |
| CHEMBL286595 | — | — | 1 | 5.82 |
| CHEMBL102403 | — | — | 1 | 5.80 |
| CHEMBL102720 | — | — | 1 | 5.69 |
| CHEMBL318513 | — | — | 1 | 5.65 |
| CHEMBL101907 | — | — | 1 | - |
| CHEMBL102541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103 | PROGESTERONE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL101914 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL320690 | — | IC50 | = | 748.0 | nM | 6.13 |
| CHEMBL103232 | — | IC50 | = | 977.0 | nM | 6.01 |
| CHEMBL103092 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL317921 | — | IC50 | = | 1062.0 | nM | 5.97 |
| CHEMBL430855 | — | IC50 | = | 1068.0 | nM | 5.97 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | IC50 | = | 1197.0 | nM | 5.92 |
| CHEMBL102754 | — | IC50 | = | 1358.0 | nM | 5.87 |
| CHEMBL286595 | — | IC50 | = | 1525.0 | nM | 5.82 |
| CHEMBL102403 | — | IC50 | = | 1592.0 | nM | 5.80 |
| CHEMBL102720 | — | IC50 | = | 2035.0 | nM | 5.69 |
| CHEMBL318513 | — | IC50 | = | 2219.0 | nM | 5.65 |
| CHEMBL101907 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL102541 | — | IC50 | > | 10000.0 | nM | - |