Assay Detail
Functional
CHEMBL729163
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against the Mineralocorticoid Receptor (MR)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
6-Aryl-1,4-dihydro-benzo[d][1,3]oxazin- 2-ones: a novel class of potent, selective, and orally active nonsteroidal progesterone receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.69 | 5.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139749 | — | — | 1 | 5.86 |
| CHEMBL136322 | — | — | 1 | 5.62 |
| CHEMBL343306 | — | — | 1 | 5.60 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | - |
| CHEMBL138059 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139749 | — | IC50 | = | 1386.0 | nM | 5.86 |
| CHEMBL136322 | — | IC50 | = | 2369.0 | nM | 5.62 |
| CHEMBL343306 | — | IC50 | = | 2492.0 | nM | 5.60 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | > | 1000.0 | nM | - |
| CHEMBL138059 | — | IC50 | > | 10000.0 | nM | - |