Assay Detail
Binding
CHEMBL729167
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human Mineralocorticoid receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as selective progesterone receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.36 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 7.85 |
| CHEMBL415524 | — | — | 1 | 6.48 |
| CHEMBL130141 | — | — | 1 | 6.44 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 5.92 |
| CHEMBL337856 | — | — | 1 | 5.73 |
| CHEMBL134277 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103 | PROGESTERONE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL415524 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL130141 | — | IC50 | = | 363.0 | nM | 6.44 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | IC50 | = | 1197.0 | nM | 5.92 |
| CHEMBL337856 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL134277 | — | IC50 | = | 1900.0 | nM | 5.72 |