Assay Detail
Functional
CHEMBL729174
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cross-reactivity as binding to human mineralocorticoid receptor (hMR)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.73 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134260 | — | — | 1 | 6.00 |
| CHEMBL131855 | — | — | 1 | 5.70 |
| CHEMBL335992 | — | — | 1 | 5.69 |
| CHEMBL132889 | — | — | 1 | 5.68 |
| CHEMBL131681 | — | — | 1 | 5.57 |
| CHEMBL117465 | — | — | 1 | - |
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134260 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL131855 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL335992 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL132889 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL131681 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL117465 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1908373 | ONAPRISTONE | IC50 | > | 1000.0 | nM | - |