Assay Detail
Functional
CHEMBL729374
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Inhibitory activity was tested against Molt4/C8 cells
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Conformational and quantitative structure-activity relationship study of cytotoxic 2-arylidenebenzocycloalkanones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 4.62 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29539 | — | — | 1 | 6.33 |
| CHEMBL28251 | — | — | 1 | 5.68 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.49 |
| CHEMBL30022 | — | — | 1 | 5.28 |
| CHEMBL30095 | — | — | 1 | 5.10 |
| CHEMBL282399 | — | — | 1 | 5.05 |
| CHEMBL281870 | — | — | 1 | 5.03 |
| CHEMBL30247 | — | — | 1 | 4.92 |
| CHEMBL29542 | — | — | 1 | 4.92 |
| CHEMBL283707 | — | — | 1 | 4.77 |
| CHEMBL28471 | — | — | 1 | 4.67 |
| CHEMBL29563 | — | — | 1 | 4.67 |
| CHEMBL29573 | — | — | 1 | 4.62 |
| CHEMBL282171 | — | — | 1 | 4.55 |
| CHEMBL28689 | — | — | 1 | 4.49 |
| CHEMBL284405 | — | — | 1 | 4.48 |
| CHEMBL29787 | — | — | 1 | 4.46 |
| CHEMBL29251 | — | — | 1 | 4.45 |
| CHEMBL282831 | — | — | 1 | 4.41 |
| CHEMBL29493 | — | — | 1 | 4.40 |
| CHEMBL29351 | — | — | 1 | 4.38 |
| CHEMBL28755 | — | — | 1 | 4.38 |
| CHEMBL417294 | — | — | 1 | 4.37 |
| CHEMBL28591 | — | — | 1 | 4.37 |
| CHEMBL282962 | — | — | 1 | 4.34 |
| CHEMBL28667 | — | — | 1 | 4.31 |
| CHEMBL413538 | — | — | 1 | 4.29 |
| CHEMBL25902 | — | — | 1 | 4.28 |
| CHEMBL27535 | — | — | 1 | 4.27 |
| CHEMBL286704 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29539 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL28251 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL852 | MELPHALAN | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL30022 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL30095 | — | IC50 | = | 8010.0 | nM | 5.10 |
| CHEMBL282399 | — | IC50 | = | 8820.0 | nM | 5.05 |
| CHEMBL281870 | — | IC50 | = | 9410.0 | nM | 5.03 |
| CHEMBL30247 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL29542 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL283707 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL28471 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL29563 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL29573 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL282171 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL28689 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL284405 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL29787 | — | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL29251 | — | IC50 | = | 35800.0 | nM | 4.45 |
| CHEMBL282831 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL29493 | — | IC50 | = | 39600.0 | nM | 4.40 |
| CHEMBL29351 | — | IC50 | = | 41800.0 | nM | 4.38 |
| CHEMBL28755 | — | IC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL417294 | — | IC50 | = | 42700.0 | nM | 4.37 |
| CHEMBL28591 | — | IC50 | = | 42300.0 | nM | 4.37 |
| CHEMBL282962 | — | IC50 | = | 46100.0 | nM | 4.34 |
| CHEMBL28667 | — | IC50 | = | 49400.0 | nM | 4.31 |
| CHEMBL413538 | — | IC50 | = | 50900.0 | nM | 4.29 |
| CHEMBL25902 | — | IC50 | = | 52600.0 | nM | 4.28 |
| CHEMBL27535 | — | IC50 | = | 53600.0 | nM | 4.27 |
| CHEMBL286704 | — | IC50 | = | 54700.0 | nM | 4.26 |
| CHEMBL29737 | — | IC50 | = | 57400.0 | nM | 4.24 |
| CHEMBL30098 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL284878 | — | IC50 | = | 80300.0 | nM | 4.09 |
| CHEMBL286526 | — | IC50 | = | 88600.0 | nM | 4.05 |
| CHEMBL417299 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL287179 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL282370 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL29077 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL28190 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL28614 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL29170 | — | IC50 | = | 173000.0 | nM | - |
| CHEMBL29042 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL29701 | — | IC50 | = | 215000.0 | nM | - |
| CHEMBL30145 | — | IC50 | = | 226000.0 | nM | - |
| CHEMBL28189 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL281551 | — | IC50 | = | 482000.0 | nM | - |
| CHEMBL281980 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL280639 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL444786 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL28855 | — | IC50 | = | 135000.0 | nM | - |