Assay Detail
Functional
CHEMBL729779
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Concentration inhibiting [3H]cocaine binding to rat striatal membranes.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of carbon-11 labeled iodinated cocaine derivatives and their distribution in baboon brain measured using positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.88 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.16 |
| CHEMBL71356 | — | — | 1 | 7.00 |
| CHEMBL304279 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370805 | COCAINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL71356 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL304279 | — | IC50 | = | 325.0 | nM | 6.49 |