Assay Detail
Binding
CHEMBL731799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Monoamine oxidase A from rat brain mitochondria
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Mitochondria |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.75 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332229 | — | — | 1 | 5.62 |
| CHEMBL339627 | — | — | 1 | 5.08 |
| CHEMBL127437 | — | — | 1 | 4.79 |
| CHEMBL340952 | — | — | 1 | 4.23 |
| CHEMBL124867 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332229 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL339627 | — | IC50 | = | 8390.0 | nM | 5.08 |
| CHEMBL127437 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL340952 | — | IC50 | = | 59100.0 | nM | 4.23 |
| CHEMBL124867 | — | IC50 | = | 97600.0 | nM | 4.01 |