Assay Detail
Binding
CHEMBL731860
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In vitro inhibition of Monoamine oxidase at rat hyphalamic mitochondrial 5-HT by displacing 2.5 uM of [14C]5-HT.
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.49 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441014 | — | — | 1 | 8.40 |
| CHEMBL8877 | — | — | 1 | 6.58 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 6.19 |
| CHEMBL8974 | — | — | 1 | 6.16 |
| CHEMBL269593 | — | — | 1 | 6.10 |
| CHEMBL268167 | — | — | 1 | 5.96 |
| CHEMBL275108 | — | — | 1 | 5.75 |
| CHEMBL8467 | — | — | 1 | 5.75 |
| CHEMBL9068 | — | — | 1 | 5.21 |
| CHEMBL8534 | — | — | 1 | 5.16 |
| CHEMBL8712 | — | — | 1 | 5.14 |
| CHEMBL8695 | — | — | 1 | 5.09 |
| CHEMBL2028089 | — | — | 2 | 4.77 |
| CHEMBL8848 | — | — | 1 | 4.70 |
| CHEMBL8956 | — | — | 1 | 4.60 |
| CHEMBL276375 | — | — | 1 | 4.54 |
| CHEMBL9064 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441014 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL8877 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL972 | SELEGILINE | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL8974 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL269593 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL268167 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL275108 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL8467 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL9068 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL8534 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL8712 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL8695 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL2028089 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL8848 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL8956 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL276375 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL9064 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL2028089 | — | IC50 | = | 51000.0 | nM | 4.29 |