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Assay Detail

CHEMBL732302

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Binding
Inhibitory activity against Monoamine oxidase A
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Amine oxidase [flavin-containing] A (CHEMBL3358)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Molecular determinants of MAO selectivity in a series of indolylmethylamine derivatives: biological activities, 3D-QSAR/CoMFA analysis, and computational simulation of ligand recognition.
Morón JA, Campillo M, Perez V, Unzeta M, Pardo L.
J Med Chem (2000) 43 : 1684 -1691
PubMed 10794685 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 6.98 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL298006 1 9.52
CHEMBL46952 1 9.09
CHEMBL44433 1 8.85
CHEMBL46898 1 8.82
CHEMBL45765 1 8.40
CHEMBL416467 1 8.37
CHEMBL298491 1 8.24
CHEMBL46491 1 6.62
CHEMBL45069 1 6.10
CHEMBL44389 1 5.40
CHEMBL46601 1 5.00
CHEMBL44430 1 4.82
CHEMBL46602 1 4.47
CHEMBL45511 1 4.06
CHEMBL47667 1 -
CHEMBL46600 1 -
CHEMBL441241 1 -
CHEMBL44487 1 -
CHEMBL43727 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL298006 Ki = 0.302 nM 9.52
CHEMBL46952 Ki = 0.8128 nM 9.09
CHEMBL44433 Ki = 1.413 nM 8.85
CHEMBL46898 Ki = 1.514 nM 8.82
CHEMBL45765 Ki = 3.981 nM 8.40
CHEMBL416467 Ki = 4.266 nM 8.37
CHEMBL298491 Ki = 5.754 nM 8.24
CHEMBL46491 Ki = 239.88 nM 6.62
CHEMBL45069 Ki = 794.33 nM 6.10
CHEMBL44389 Ki = 3981.07 nM 5.40
CHEMBL46601 Ki = 10000.0 nM 5.00
CHEMBL44430 Ki = 15135.61 nM 4.82
CHEMBL46602 Ki = 33884.42 nM 4.47
CHEMBL45511 Ki = 87096.36 nM 4.06
CHEMBL47667 Ki = 245470.89 nM -
CHEMBL46600 Ki = 131825.67 nM -
CHEMBL441241 Ki = 165958.69 nM -
CHEMBL44487 Ki = 263026.8 nM -
CHEMBL43727 Ki = 158489.32 nM -