Assay Detail
Binding
CHEMBL732386
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against rat brain mitochondrial monoamine oxidase A
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Selective inhibitors of monoamine oxidase. 3. Structure-activity relationship of tricyclics bearing imidazoline, oxadiazole, or tetrazole groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.49 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54762 | — | — | 1 | 9.00 |
| CHEMBL301088 | — | — | 1 | 8.70 |
| CHEMBL279991 | — | — | 1 | 8.70 |
| CHEMBL292927 | — | — | 1 | 8.70 |
| CHEMBL52887 | — | — | 1 | 8.70 |
| CHEMBL300999 | — | — | 1 | 8.70 |
| CHEMBL55938 | — | — | 1 | 8.30 |
| CHEMBL54442 | — | — | 1 | 8.15 |
| CHEMBL55703 | — | — | 1 | 8.05 |
| CHEMBL54760 | — | — | 1 | 8.00 |
| CHEMBL436558 | — | — | 1 | 8.00 |
| CHEMBL53392 | — | — | 1 | 8.00 |
| CHEMBL54908 | — | — | 1 | 8.00 |
| CHEMBL52762 | — | — | 1 | 8.00 |
| CHEMBL55372 | — | — | 1 | 7.70 |
| CHEMBL301390 | — | — | 1 | 7.70 |
| CHEMBL55134 | — | — | 1 | 7.70 |
| CHEMBL297730 | — | — | 1 | 7.70 |
| CHEMBL54424 | — | — | 1 | 7.64 |
| CHEMBL54967 | — | — | 1 | 7.40 |
| CHEMBL55226 | — | — | 1 | 7.40 |
| CHEMBL55369 | — | — | 1 | 7.40 |
| CHEMBL52477 | — | — | 1 | 7.40 |
| CHEMBL55947 | — | — | 1 | 7.30 |
| CHEMBL301087 | — | — | 1 | 7.22 |
| CHEMBL439746 | — | — | 1 | 7.16 |
| CHEMBL300244 | — | — | 1 | 7.10 |
| CHEMBL55105 | — | — | 1 | 7.10 |
| CHEMBL301625 | — | — | 1 | 7.00 |
| CHEMBL55927 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54762 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL301088 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL279991 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL292927 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL52887 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL300999 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL55938 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL54442 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL55703 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL436558 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL52762 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL54908 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL53392 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL54760 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL297730 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL55372 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL55134 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL301390 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL54424 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL54967 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL52477 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL55226 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL55369 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL55947 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL301087 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL439746 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL300244 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL55105 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL301625 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL55927 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL55045 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL56007 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL291904 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL57110 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL55831 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL53617 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL300196 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL55674 | — | IC50 | = | 2000.0 | nM | 5.70 |