Assay Detail
Binding
CHEMBL732389
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Inhibitory concentration towards monoamine oxidase A in rat brain was measured
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.37 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436947 | — | — | 1 | 8.52 |
| CHEMBL371428 | — | — | 1 | 6.52 |
| CHEMBL255231 | LADOSTIGIL | 2.0 | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436947 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL371428 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL255231 | LADOSTIGIL | IC50 | = | 85000.0 | nM | 4.07 |