Assay Detail
Binding
CHEMBL732489
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Inhibition of Mixed lineage kinase 2(MLK2)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Mitogen-activated protein kinase kinase kinase 10 (CHEMBL2873) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Mixed lineage kinase activity of indolocarbazole analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.21 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288817 | — | — | 1 | 7.80 |
| CHEMBL277817 | — | — | 1 | 7.70 |
| CHEMBL288229 | — | — | 1 | 7.55 |
| CHEMBL290352 | CEP-1347 | 3.0 | 1 | 7.29 |
| CHEMBL288816 | — | — | 1 | 7.05 |
| CHEMBL36891 | — | — | 1 | 6.85 |
| CHEMBL29709 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288817 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL277817 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL288229 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL290352 | CEP-1347 | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL288816 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL36891 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL29709 | — | IC50 | = | 627.0 | nM | 6.20 |