Assay Detail
Binding
CHEMBL732561
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Binding affinity towards monoamine oxidase A activity was measured using a kynuramine assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.35 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371428 | — | — | 1 | 5.72 |
| CHEMBL436947 | — | — | 1 | 5.31 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 5.01 |
| CHEMBL255231 | LADOSTIGIL | 2.0 | 1 | - |
| CHEMBL1235738 | AZILECT | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371428 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL436947 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL887 | RASAGILINE | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL255231 | LADOSTIGIL | Ki | = | 227000.0 | nM | - |
| CHEMBL1235738 | AZILECT | Ki | = | 112000.0 | nM | - |