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Assay Detail

CHEMBL733064

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Binding
Ability to inhibit Monoamine oxidase A enzyme
ChEMBL ↗
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Amine oxidase [flavin-containing] A (CHEMBL3358) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Inhibition of monoamine oxidase-B by 5H-indeno[1,2-c]pyridazines: biological activities, quantitative structure-activity relationships (QSARs) and 3D-QSARs.
Kneubühler S, Thull U, Altomare C, Carta V, Gaillard P, Carrupt PA, Carotti A, Testa B.
J Med Chem (1995) 38 : 3874 -3883
PubMed 7562919 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 66 4.94 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL127983 — — 1 6.00
CHEMBL125921 — — 1 6.00
CHEMBL339739 — — 1 6.00
CHEMBL339535 — — 1 6.00
CHEMBL341073 — — 1 6.00
CHEMBL127758 — — 1 6.00
CHEMBL126561 — — 1 6.00
CHEMBL127077 — — 1 6.00
CHEMBL127622 — — 1 6.00
CHEMBL127717 — — 1 6.00
CHEMBL127182 — — 1 6.00
CHEMBL338094 — — 1 6.00
CHEMBL123803 — — 1 6.00
CHEMBL339470 — — 1 5.30
CHEMBL125520 — — 1 5.30
CHEMBL127751 — — 1 5.00
CHEMBL340239 — — 1 5.00
CHEMBL126027 — — 1 5.00
CHEMBL126891 — — 1 5.00
CHEMBL127982 — — 1 5.00
CHEMBL339561 — — 1 5.00
CHEMBL127347 — — 1 5.00
CHEMBL126886 — — 1 5.00
CHEMBL126419 — — 1 5.00
CHEMBL125044 — — 1 5.00
CHEMBL124461 — — 1 5.00
CHEMBL421088 — — 1 4.60
CHEMBL339429 — — 1 4.60
CHEMBL124935 — — 1 4.60
CHEMBL339445 — — 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL127983 — IC50 = 1000.0 nM 6.00
CHEMBL125921 — IC50 = 1000.0 nM 6.00
CHEMBL339739 — IC50 = 1000.0 nM 6.00
CHEMBL339535 — IC50 = 1000.0 nM 6.00
CHEMBL341073 — IC50 = 1000.0 nM 6.00
CHEMBL127758 — IC50 = 1000.0 nM 6.00
CHEMBL126561 — IC50 = 1000.0 nM 6.00
CHEMBL127077 — IC50 = 1000.0 nM 6.00
CHEMBL127622 — IC50 = 1000.0 nM 6.00
CHEMBL127717 — IC50 = 1000.0 nM 6.00
CHEMBL127182 — IC50 = 1000.0 nM 6.00
CHEMBL338094 — IC50 = 1000.0 nM 6.00
CHEMBL123803 — IC50 = 1000.0 nM 6.00
CHEMBL339470 — IC50 = 5000.0 nM 5.30
CHEMBL125520 — IC50 = 5000.0 nM 5.30
CHEMBL340239 — IC50 = 10000.0 nM 5.00
CHEMBL126027 — IC50 = 10000.0 nM 5.00
CHEMBL126891 — IC50 = 10000.0 nM 5.00
CHEMBL127982 — IC50 = 10000.0 nM 5.00
CHEMBL339561 — IC50 = 10000.0 nM 5.00
CHEMBL126886 — IC50 = 10000.0 nM 5.00
CHEMBL126419 — IC50 = 10000.0 nM 5.00
CHEMBL125044 — IC50 = 10000.0 nM 5.00
CHEMBL124461 — IC50 = 10000.0 nM 5.00
CHEMBL127751 — IC50 = 10000.0 nM 5.00
CHEMBL127347 — IC50 = 10000.0 nM 5.00
CHEMBL339445 — IC50 = 25000.0 nM 4.60
CHEMBL124935 — IC50 = 25000.0 nM 4.60
CHEMBL339429 — IC50 = 25000.0 nM 4.60
CHEMBL421088 — IC50 = 25000.0 nM 4.60
CHEMBL339794 — IC50 = 25900.0 nM 4.59
CHEMBL129769 — IC50 = 31000.0 nM 4.51
CHEMBL340701 — IC50 = 30600.0 nM 4.51
CHEMBL127880 — IC50 = 34300.0 nM 4.46
CHEMBL341240 — IC50 = 36800.0 nM 4.43
CHEMBL339107 — IC50 = 50500.0 nM 4.30
CHEMBL340028 — IC50 = 50000.0 nM 4.30
CHEMBL127567 — IC50 = 50000.0 nM 4.30
CHEMBL126504 — IC50 = 50000.0 nM 4.30
CHEMBL125094 — IC50 = 50000.0 nM 4.30
CHEMBL125540 — IC50 = 50000.0 nM 4.30
CHEMBL340130 — IC50 = 50000.0 nM 4.30
CHEMBL126505 — IC50 = 50000.0 nM 4.30
CHEMBL124867 — IC50 = 97600.0 nM 4.01
CHEMBL123894 — IC50 = 100000.0 nM 4.00
CHEMBL123895 — IC50 = 100000.0 nM 4.00
CHEMBL126133 — IC50 = 100000.0 nM 4.00
CHEMBL129270 — IC50 = 100000.0 nM 4.00
CHEMBL126799 — IC50 = 100000.0 nM 4.00
CHEMBL338035 — IC50 = 100000.0 nM 4.00