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Assay Detail

CHEMBL733093

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mitochondrial Monoamine oxidase-B purified from bovine liver
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

New analogues of N-(2-aminoethyl)-4-chlorobenzamide (Ro 16-6491). Some of the most potent monoamine oxidase-B inactivators.
Annan N, Silverman RB.
J Med Chem (1993) 36 : 3968 -3970
PubMed 8254625 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.57 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL279390 LAZABEMIDE 2.0 1 7.52
CHEMBL128015 1 7.43
CHEMBL127386 1 7.38
CHEMBL338404 1 7.35
CHEMBL128615 1 7.28
CHEMBL128669 1 7.25
CHEMBL129755 1 7.22
CHEMBL130698 1 6.92
CHEMBL129168 1 6.80
CHEMBL129248 1 6.77
CHEMBL338590 1 6.70
CHEMBL128277 1 6.60
CHEMBL130138 1 6.31
CHEMBL128150 1 5.92
CHEMBL341153 1 5.66
CHEMBL129914 1 4.32
CHEMBL340246 1 4.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL279390 LAZABEMIDE IC50 = 30.0 nM 7.52
CHEMBL128015 IC50 = 37.0 nM 7.43
CHEMBL127386 IC50 = 42.0 nM 7.38
CHEMBL338404 IC50 = 45.0 nM 7.35
CHEMBL128615 IC50 = 52.0 nM 7.28
CHEMBL128669 IC50 = 56.0 nM 7.25
CHEMBL129755 IC50 = 60.0 nM 7.22
CHEMBL130698 IC50 = 120.0 nM 6.92
CHEMBL129168 IC50 = 160.0 nM 6.80
CHEMBL129248 IC50 = 170.0 nM 6.77
CHEMBL338590 IC50 = 200.0 nM 6.70
CHEMBL128277 IC50 = 250.0 nM 6.60
CHEMBL130138 IC50 = 490.0 nM 6.31
CHEMBL128150 IC50 = 1200.0 nM 5.92
CHEMBL341153 IC50 = 2170.0 nM 5.66
CHEMBL129914 IC50 = 48200.0 nM 4.32
CHEMBL340246 IC50 = 61500.0 nM 4.21