Assay Detail
Binding
CHEMBL733230
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In vitro inhibitory activity against rat brain Monoamine oxidase A
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Selective and potent monoamine oxidase type B inhibitors: 2-substituted 5-aryltetrazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 4.70 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340807 | HARMALINE | — | 1 | 7.92 |
| CHEMBL144945 | — | — | 1 | 5.34 |
| CHEMBL356737 | — | — | 1 | 5.19 |
| CHEMBL145330 | — | — | 1 | 5.11 |
| CHEMBL341851 | — | — | 1 | 5.02 |
| CHEMBL145596 | — | — | 1 | 4.96 |
| CHEMBL145435 | — | — | 1 | 4.89 |
| CHEMBL341850 | — | — | 1 | 4.78 |
| CHEMBL142778 | — | — | 1 | 4.75 |
| CHEMBL142723 | — | — | 1 | 4.58 |
| CHEMBL145511 | — | — | 1 | 4.34 |
| CHEMBL342916 | — | — | 1 | 4.34 |
| CHEMBL144926 | — | — | 1 | 4.27 |
| CHEMBL141933 | — | — | 1 | 4.24 |
| CHEMBL141992 | — | — | 1 | 4.22 |
| CHEMBL145760 | — | — | 1 | 4.19 |
| CHEMBL145044 | — | — | 1 | 4.18 |
| CHEMBL144700 | — | — | 1 | 4.10 |
| CHEMBL145434 | — | — | 1 | 4.10 |
| CHEMBL434261 | — | — | 1 | 4.07 |
| CHEMBL145111 | — | — | 1 | 4.06 |
| CHEMBL356516 | — | — | 1 | - |
| CHEMBL145513 | — | — | 1 | - |
| CHEMBL145052 | — | — | 1 | - |
| CHEMBL146385 | — | — | 1 | - |
| CHEMBL347991 | — | — | 1 | - |
| CHEMBL279390 | LAZABEMIDE | 2.0 | 1 | - |
| CHEMBL359398 | — | — | 1 | - |
| CHEMBL358587 | — | — | 1 | - |
| CHEMBL145748 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340807 | HARMALINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL144945 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL356737 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL145330 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL341851 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL145596 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL145435 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL341850 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL142778 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL142723 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL145511 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL342916 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL144926 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL141933 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL141992 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL145760 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL145044 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL144700 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL145434 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL434261 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL145111 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL343248 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL358449 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL142909 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL143032 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL144260 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL144971 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL357152 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL145542 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL142895 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL342557 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL356349 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL145150 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL145748 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL358587 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL359398 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL279390 | LAZABEMIDE | IC50 | > | 10000.0 | nM | - |
| CHEMBL347991 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL146385 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL145052 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL145513 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL356516 | — | IC50 | > | 100000.0 | nM | - |