Assay Detail
Binding
CHEMBL733231
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In vitro inhibitory against monoamine oxidase A (MAO-A) in rat brain homogenate.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of coumarins as subtype-selective inhibitors of monoamine oxidase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.11 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160347 | BROFAROMINE | 2.0 | 1 | 8.30 |
| CHEMBL278508 | — | — | 1 | 8.30 |
| CHEMBL278974 | — | — | 1 | 8.22 |
| CHEMBL18504 | ESUPRONE | 2.0 | 1 | 8.10 |
| CHEMBL416175 | — | — | 1 | 8.10 |
| CHEMBL274030 | — | — | 1 | 7.92 |
| CHEMBL276076 | — | — | 1 | 7.89 |
| CHEMBL18503 | — | — | 1 | 7.80 |
| CHEMBL18978 | — | — | 1 | 7.62 |
| CHEMBL18669 | — | — | 1 | 7.47 |
| CHEMBL274029 | — | — | 1 | 7.15 |
| CHEMBL18492 | — | — | 1 | 6.96 |
| CHEMBL274746 | — | — | 1 | 6.72 |
| CHEMBL18966 | — | — | 1 | 6.25 |
| CHEMBL18153 | — | — | 1 | 5.75 |
| CHEMBL18832 | — | — | 1 | 5.25 |
| CHEMBL274513 | — | — | 1 | 5.16 |
| CHEMBL18317 | — | — | 1 | 5.00 |
| CHEMBL18425 | — | — | 1 | - |
| CHEMBL279390 | LAZABEMIDE | 2.0 | 1 | - |
| CHEMBL19004 | ATIBEPRONE | 2.0 | 1 | - |
| CHEMBL19240 | — | — | 1 | - |
| CHEMBL19183 | — | — | 1 | - |
| CHEMBL18327 | — | — | 1 | - |
| CHEMBL18042 | — | — | 1 | - |
| CHEMBL415992 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160347 | BROFAROMINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL278508 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL278974 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL18504 | ESUPRONE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL416175 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL274030 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL276076 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL18503 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL18978 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL18669 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL274029 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL18492 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL274746 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL18966 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL18153 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL18832 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL274513 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL18317 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL18425 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL279390 | LAZABEMIDE | IC50 | > | 10000.0 | nM | - |
| CHEMBL19004 | ATIBEPRONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL19240 | — | IC50 | ~ | 10000.0 | nM | - |
| CHEMBL19183 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL18327 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL18042 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL415992 | — | IC50 | > | 10000.0 | nM | - |