Assay Detail
Binding
CHEMBL733232
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In vitro inhibitory concentration against Monoamine oxidase A of rat brain homogenates
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.21 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436947 | — | — | 1 | 8.52 |
| CHEMBL2096744 | — | — | 1 | 7.16 |
| CHEMBL1235738 | AZILECT | — | 1 | 4.66 |
| CHEMBL542265 | — | — | 1 | 4.50 |
| CHEMBL544635 | — | — | 1 | - |
| CHEMBL555919 | — | — | 1 | - |
| CHEMBL542506 | — | — | 1 | - |
| CHEMBL1788300 | — | — | 1 | - |
| CHEMBL151388 | — | — | 1 | - |
| CHEMBL556028 | — | — | 1 | - |
| CHEMBL545797 | — | — | 1 | - |
| CHEMBL148760 | — | — | 1 | - |
| CHEMBL542266 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436947 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2096744 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1235738 | AZILECT | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL542265 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL544635 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL555919 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL542506 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL1788300 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL151388 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL556028 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL545797 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL148760 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL542266 | — | IC50 | = | 1000000.0 | nM | - |