Assay Detail
Binding
CHEMBL733652
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Binding affinity was determined as the ability to displace [3H]4''CD from the (mDRC) mitochondrial DBI receptor complex using primary cultures of glial cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of benzofuran-acetamides as "antineophobic" mitochondrial DBI receptor complex ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.70 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63154 | — | — | 1 | 8.36 |
| CHEMBL63246 | — | — | 1 | 8.10 |
| CHEMBL65912 | — | — | 1 | 7.85 |
| CHEMBL65422 | — | — | 1 | 7.50 |
| CHEMBL63668 | — | — | 1 | 7.50 |
| CHEMBL65421 | — | — | 1 | 7.46 |
| CHEMBL302381 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63154 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL63246 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL65912 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL65422 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL63668 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL65421 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL302381 | — | Ki | = | 80.0 | nM | 7.10 |