Assay Detail
Binding
CHEMBL733653
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Ability to inhibit mitochondrial malate dehydrogenase
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-hydroxyquinoline-3-carboxylic acids as inhibitors of cell respiration. 2. Quantitative structure-activity relationship of dehydrogenase enzyme and Ehrlich ascites tumor cell inhibitions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.15 | 5.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434275 | — | — | 1 | 5.83 |
| CHEMBL156707 | — | — | 1 | 5.80 |
| CHEMBL348630 | — | — | 1 | 5.74 |
| CHEMBL155684 | — | — | 1 | 5.66 |
| CHEMBL160429 | — | — | 1 | 5.61 |
| CHEMBL160432 | — | — | 1 | 5.60 |
| CHEMBL160455 | — | — | 1 | 5.39 |
| CHEMBL157654 | — | — | 1 | 5.32 |
| CHEMBL156108 | — | — | 1 | 5.32 |
| CHEMBL351558 | — | — | 1 | 5.29 |
| CHEMBL160792 | — | — | 1 | 5.17 |
| CHEMBL155958 | — | — | 1 | 4.88 |
| CHEMBL160167 | — | — | 1 | 4.83 |
| CHEMBL155672 | — | — | 1 | 4.74 |
| CHEMBL157710 | — | — | 1 | 4.49 |
| CHEMBL351540 | — | — | 1 | 4.42 |
| CHEMBL156384 | — | — | 1 | 4.40 |
| CHEMBL157580 | — | — | 1 | 4.22 |
| CHEMBL139244 | — | — | 1 | - |
| CHEMBL344461 | — | — | 1 | - |
| CHEMBL139078 | — | — | 1 | - |
| CHEMBL139402 | — | — | 1 | - |
| CHEMBL138298 | — | — | 1 | - |
| CHEMBL1161215 | — | — | 1 | - |
| CHEMBL345688 | — | — | 1 | - |
| CHEMBL343799 | — | — | 1 | - |
| CHEMBL141025 | — | — | 1 | - |
| CHEMBL160456 | — | — | 1 | - |
| CHEMBL138027 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434275 | — | IC50 | = | 1479.11 | nM | 5.83 |
| CHEMBL156707 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL348630 | — | IC50 | = | 1819.7 | nM | 5.74 |
| CHEMBL155684 | — | IC50 | = | 2187.76 | nM | 5.66 |
| CHEMBL160429 | — | IC50 | = | 2454.71 | nM | 5.61 |
| CHEMBL160432 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL160455 | — | IC50 | = | 4073.8 | nM | 5.39 |
| CHEMBL157654 | — | IC50 | = | 4786.3 | nM | 5.32 |
| CHEMBL156108 | — | IC50 | = | 4786.3 | nM | 5.32 |
| CHEMBL351558 | — | IC50 | = | 5128.61 | nM | 5.29 |
| CHEMBL160792 | — | IC50 | = | 6760.83 | nM | 5.17 |
| CHEMBL155958 | — | IC50 | = | 13182.57 | nM | 4.88 |
| CHEMBL160167 | — | IC50 | = | 14791.08 | nM | 4.83 |
| CHEMBL155672 | — | IC50 | = | 18197.01 | nM | 4.74 |
| CHEMBL157710 | — | IC50 | = | 32359.37 | nM | 4.49 |
| CHEMBL351540 | — | IC50 | = | 38018.94 | nM | 4.42 |
| CHEMBL156384 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL157580 | — | IC50 | = | 60255.96 | nM | 4.22 |
| CHEMBL139244 | — | IC50 | = | 1905460.72 | nM | - |
| CHEMBL344461 | — | IC50 | = | 3630780.55 | nM | - |
| CHEMBL139078 | — | IC50 | = | 1071519.31 | nM | - |
| CHEMBL139402 | — | IC50 | = | 954992.59 | nM | - |
| CHEMBL138298 | — | IC50 | = | 478630.09 | nM | - |
| CHEMBL1161215 | — | IC50 | = | 2137962.09 | nM | - |
| CHEMBL345688 | — | IC50 | = | 10471285.48 | nM | - |
| CHEMBL343799 | — | IC50 | = | 660693.45 | nM | - |
| CHEMBL141025 | — | IC50 | = | 912010.84 | nM | - |
| CHEMBL160456 | — | IC50 | = | 741310.24 | nM | - |
| CHEMBL138027 | — | IC50 | = | 489778.82 | nM | - |