Assay Detail
Binding
CHEMBL734179
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Inhibitory concentration against Monoamine oxidase B was measured in baboon liver.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Papio hamadryas |
| Tissue | Liver |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Rational approaches towards reversible inhibition of type B monoamine oxidase. Design and evaluation of a novel 5H-Indeno[1,2-c]pyridazin-5-one derivative.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.33 | 10.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348961 | — | — | 1 | 10.85 |
| CHEMBL434261 | — | — | 1 | 8.70 |
| CHEMBL17092 | — | — | 1 | 8.66 |
| CHEMBL17079 | — | — | 1 | 8.36 |
| CHEMBL16530 | — | — | 1 | 8.10 |
| CHEMBL16623 | — | — | 1 | 7.80 |
| CHEMBL350093 | — | — | 1 | 7.75 |
| CHEMBL161896 | — | — | 1 | 7.70 |
| CHEMBL127983 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348961 | — | IC50 | = | 0.014 | nM | 10.85 |
| CHEMBL434261 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL17092 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL17079 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL16530 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL16623 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL350093 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL161896 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL127983 | — | IC50 | = | 90.0 | nM | 7.05 |