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Assay Detail

CHEMBL734659

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Binding
Inhibitory activity against rat brain mitochondrial Monoamine oxidase
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Monoamine oxidase (CHEMBL2095196)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Enzyme-activated irreversible inhibitors of monoamine oxidase: phenylallylamine structure-activity relationships.
McDonald IA, Lacoste JM, Bey P, Palfreyman MG, Zreika M.
J Med Chem (1985) 28 : 186 -193
PubMed 3968682 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.55 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL554775 1 8.30
CHEMBL544509 1 8.15
CHEMBL555332 1 8.00
CHEMBL545207 1 7.75
CHEMBL541803 1 7.70
CHEMBL972 SELEGILINE 4.0 1 7.60
CHEMBL538992 1 7.30
CHEMBL543328 1 7.22
CHEMBL553995 1 7.00
CHEMBL545677 1 6.82
CHEMBL538744 1 5.60
CHEMBL535873 1 5.60
CHEMBL544271 1 5.00
CHEMBL555774 1 4.40
CHEMBL539507 CLORGYLINE HYDROCHLORIDE 1 4.30
CHEMBL544507 1 4.00
CHEMBL544742 1 -
CHEMBL544745 1 -
CHEMBL57286 ALLYLAMINE 1 -
CHEMBL544506 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL554775 IC50 = 5.0 nM 8.30
CHEMBL544509 IC50 = 7.0 nM 8.15
CHEMBL555332 IC50 = 10.0 nM 8.00
CHEMBL545207 IC50 = 18.0 nM 7.75
CHEMBL541803 IC50 = 20.0 nM 7.70
CHEMBL972 SELEGILINE IC50 = 25.0 nM 7.60
CHEMBL538992 IC50 = 50.0 nM 7.30
CHEMBL543328 IC50 = 60.0 nM 7.22
CHEMBL553995 IC50 = 100.0 nM 7.00
CHEMBL545677 IC50 = 150.0 nM 6.82
CHEMBL538744 IC50 = 2500.0 nM 5.60
CHEMBL535873 IC50 = 2500.0 nM 5.60
CHEMBL544271 IC50 = 10000.0 nM 5.00
CHEMBL555774 IC50 = 40000.0 nM 4.40
CHEMBL539507 CLORGYLINE HYDROCHLORIDE IC50 = 50000.0 nM 4.30
CHEMBL544507 IC50 = 100000.0 nM 4.00
CHEMBL544742 IC50 = 500000.0 nM -
CHEMBL544745 IC50 = 400000.0 nM -
CHEMBL57286 ALLYLAMINE IC50 = 500000.0 nM -
CHEMBL544506 IC50 = 500000.0 nM -