Assay Detail
Binding
CHEMBL734668
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Binding affinity against Monoclonal antibody mAB-1B3 using [3H]digoxin as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Intermediate |
Publication
Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.61 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254219 | DIGITOXIN | 4.0 | 1 | 10.00 |
| CHEMBL1751 | DIGOXIN | 4.0 | 1 | 8.92 |
| CHEMBL1453 | DIGITOXIGENIN | — | 1 | 6.00 |
| CHEMBL1153 | DIGOXIGENIN | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254219 | DIGITOXIN | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL1751 | DIGOXIN | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1453 | DIGITOXIGENIN | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1153 | DIGOXIGENIN | Ki | = | 3100.0 | nM | 5.51 |