Assay Detail
Binding
CHEMBL734672
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Relative binding affinity against human monoclonal antibody 2E2 compared to [3H]cocaine
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Three-dimensional quantitative structure-activity relationship modeling of cocaine binding by a novel human monoclonal antibody.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.29 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL608806 | COCAETHYLENE | 1.0 | 1 | 8.47 |
| CHEMBL608547 | — | — | 1 | 7.37 |
| CHEMBL612016 | — | — | 1 | 5.28 |
| CHEMBL612017 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608806 | COCAETHYLENE | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL608547 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL612016 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL612017 | — | Ki | = | 95000.0 | nM | 4.02 |