Assay Detail
Functional
CHEMBL740149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.48 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341280 | — | — | 1 | 8.92 |
| CHEMBL129677 | — | — | 1 | 8.15 |
| CHEMBL118928 | — | — | 1 | 7.50 |
| CHEMBL125846 | — | — | 1 | 7.39 |
| CHEMBL129760 | — | — | 1 | 7.21 |
| CHEMBL340203 | — | — | 1 | 7.12 |
| CHEMBL261454 | — | — | 1 | 7.05 |
| CHEMBL129153 | — | — | 1 | 6.83 |
| CHEMBL125738 | — | — | 1 | 6.38 |
| CHEMBL129678 | — | — | 1 | 6.28 |
| CHEMBL338196 | — | — | 1 | 6.27 |
| CHEMBL126789 | — | — | 1 | 6.17 |
| CHEMBL126180 | — | — | 1 | 5.87 |
| CHEMBL338713 | — | — | 1 | 5.78 |
| CHEMBL129553 | — | — | 1 | 5.67 |
| CHEMBL337978 | — | — | 1 | 5.59 |
| CHEMBL130025 | — | — | 1 | 5.55 |
| CHEMBL126676 | — | — | 1 | 5.54 |
| CHEMBL341534 | — | — | 1 | 5.33 |
| CHEMBL129280 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341280 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL129677 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL118928 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL125846 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL129760 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL340203 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL261454 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL129153 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL125738 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL129678 | — | IC50 | = | 524.0 | nM | 6.28 |
| CHEMBL338196 | — | IC50 | = | 538.0 | nM | 6.27 |
| CHEMBL126789 | — | IC50 | = | 683.0 | nM | 6.17 |
| CHEMBL126180 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL338713 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL129553 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL337978 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL130025 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL126676 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL341534 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL129280 | — | IC50 | = | 9540.0 | nM | 5.02 |