Assay Detail
Binding
CHEMBL740208
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Tested in vitro for serotonin(5-HT) neuronal uptake inhibition
30
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL4642) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Pyrroloisoquinoline antidepressants. 3. A focus on serotonin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 8.17 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327790 | — | — | 3 | 9.41 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 9.36 |
| CHEMBL330666 | — | — | 1 | 9.00 |
| CHEMBL285506 | — | — | 1 | 8.75 |
| CHEMBL555462 | — | — | 1 | 8.62 |
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | 8.54 |
| CHEMBL96362 | — | — | 1 | 8.54 |
| CHEMBL539803 | — | — | 1 | 8.52 |
| CHEMBL554191 | — | — | 1 | 8.52 |
| CHEMBL94711 | — | — | 1 | 8.49 |
| CHEMBL541308 | — | — | 1 | 8.39 |
| CHEMBL94738 | — | — | 1 | 8.32 |
| CHEMBL329216 | — | — | 1 | 8.10 |
| CHEMBL94508 | — | — | 1 | 8.09 |
| CHEMBL555655 | — | — | 1 | 8.07 |
| CHEMBL94739 | FEMOXETINE | 2.0 | 1 | 8.04 |
| CHEMBL94535 | — | — | 1 | 8.01 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 7.97 |
| CHEMBL94665 | — | — | 1 | 7.90 |
| CHEMBL545724 | — | — | 1 | 7.83 |
| CHEMBL95153 | — | — | 1 | 7.81 |
| CHEMBL284305 | — | — | 1 | 7.78 |
| CHEMBL328818 | — | — | 1 | 7.72 |
| CHEMBL35184 | — | — | 1 | 7.63 |
| CHEMBL93035 | — | — | 1 | 7.54 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 7.38 |
| CHEMBL96615 | — | — | 1 | 6.22 |
| CHEMBL555404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327790 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL490 | PAROXETINE | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL327790 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL330666 | — | Ki | = | 1.01 | nM | 9.00 |
| CHEMBL285506 | — | Ki | = | 1.76 | nM | 8.75 |
| CHEMBL555462 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL549 | CITALOPRAM | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL96362 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL539803 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL554191 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL94711 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL541308 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL94738 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL329216 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL94508 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL555655 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL94739 | FEMOXETINE | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL94535 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL41 | FLUOXETINE | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL94665 | — | Ki | = | 12.7 | nM | 7.90 |
| CHEMBL545724 | — | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL95153 | — | Ki | = | 15.6 | nM | 7.81 |
| CHEMBL284305 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL328818 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL35184 | — | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL93035 | — | Ki | = | 29.2 | nM | 7.54 |
| CHEMBL11 | IMIPRAMINE | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL327790 | — | Ki | = | 58.4 | nM | 7.23 |
| CHEMBL96615 | — | Ki | = | 597.0 | nM | 6.22 |
| CHEMBL555404 | — | Ki | ~ | 100.0 | nM | - |