Assay Detail
Functional
CHEMBL743818
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Concentration required to inhibit proliferation of Human lung carcinoma NCI-H460 cell line
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.07 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423439 | — | — | 1 | 8.57 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.52 |
| CHEMBL169298 | — | — | 1 | 8.51 |
| CHEMBL171222 | — | — | 1 | 7.54 |
| CHEMBL424367 | — | — | 1 | 7.39 |
| CHEMBL355523 | — | — | 1 | 7.33 |
| CHEMBL47426 | — | — | 1 | 7.22 |
| CHEMBL171882 | — | — | 1 | 7.17 |
| CHEMBL354644 | — | — | 1 | 6.85 |
| CHEMBL312992 | — | — | 1 | 6.85 |
| CHEMBL170284 | — | — | 1 | 6.32 |
| CHEMBL169800 | — | — | 1 | 6.27 |
| CHEMBL171143 | — | — | 1 | 6.26 |
| CHEMBL169554 | — | — | 1 | 6.21 |
| CHEMBL172111 | — | — | 1 | 6.13 |
| CHEMBL170231 | — | — | 1 | 6.05 |
| CHEMBL423077 | — | — | 1 | - |
| CHEMBL353014 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423439 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL169298 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL171222 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL424367 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL355523 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL47426 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL171882 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL354644 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL312992 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL170284 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL169800 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL171143 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL169554 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL172111 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL170231 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL423077 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL353014 | — | IC50 | > | 10000.0 | nM | - |