Assay Detail
Binding
CHEMBL744184
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for binding to Norepinephrine Transporter (NET) using [3H]desmethylimipramine as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.63 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084927 | — | — | 1 | 6.24 |
| CHEMBL11493 | — | — | 1 | 5.88 |
| CHEMBL12375 | — | — | 1 | 5.68 |
| CHEMBL12227 | — | — | 1 | 5.45 |
| CHEMBL440272 | — | — | 1 | 5.32 |
| CHEMBL417249 | — | — | 1 | 5.23 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084927 | — | Ki | = | 577.0 | nM | 6.24 |
| CHEMBL11493 | — | Ki | = | 1330.0 | nM | 5.88 |
| CHEMBL12375 | — | Ki | = | 2080.0 | nM | 5.68 |
| CHEMBL12227 | — | Ki | = | 3520.0 | nM | 5.45 |
| CHEMBL440272 | — | Ki | = | 4790.0 | nM | 5.32 |
| CHEMBL417249 | — | Ki | = | 5920.0 | nM | 5.23 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | Ki | > | 8500.0 | nM | - |