Assay Detail
Functional
CHEMBL744193
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Tested against OVCAR-3 human ovarian cancer cells by sulforhodamine B (SRB) assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2-substituted 1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones. A new class of antitumor agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.12 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423257 | — | — | 1 | 7.36 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.24 |
| CHEMBL165018 | — | — | 1 | 7.18 |
| CHEMBL349402 | — | — | 1 | 7.09 |
| CHEMBL348916 | — | — | 1 | 7.05 |
| CHEMBL351618 | — | — | 1 | 6.79 |
| CHEMBL166257 | — | — | 1 | 6.69 |
| CHEMBL166139 | — | — | 1 | 6.67 |
| CHEMBL165977 | — | — | 1 | 6.33 |
| CHEMBL165858 | — | — | 1 | 6.19 |
| CHEMBL166062 | — | — | 1 | 5.93 |
| CHEMBL163792 | — | — | 1 | 5.71 |
| CHEMBL166129 | — | — | 1 | 5.71 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.66 |
| CHEMBL434285 | — | — | 1 | 5.61 |
| CHEMBL350519 | — | — | 1 | 5.41 |
| CHEMBL164825 | — | — | 1 | 5.10 |
| CHEMBL165170 | — | — | 1 | 5.10 |
| CHEMBL351023 | — | — | 1 | 4.79 |
| CHEMBL166191 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423257 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL165018 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL349402 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL348916 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL351618 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL166257 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL166139 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL165977 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL165858 | — | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL166062 | — | IC50 | = | 1185.0 | nM | 5.93 |
| CHEMBL163792 | — | IC50 | = | 1939.0 | nM | 5.71 |
| CHEMBL166129 | — | IC50 | = | 1968.0 | nM | 5.71 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL434285 | — | IC50 | = | 2434.0 | nM | 5.61 |
| CHEMBL350519 | — | IC50 | = | 3866.0 | nM | 5.41 |
| CHEMBL164825 | — | IC50 | = | 8021.0 | nM | 5.10 |
| CHEMBL165170 | — | IC50 | = | 7911.0 | nM | 5.10 |
| CHEMBL351023 | — | IC50 | = | 16169.0 | nM | 4.79 |
| CHEMBL166191 | — | IC50 | = | 17380.0 | nM | 4.76 |