Assay Detail

CHEMBL744385

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Binding

Inhibition of [3H]pirenzepine binding towards muscarinic acetylcholine receptor in rat brain.

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Tissue	Brain
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Crystal, solution, and molecular modeling structural properties and muscarinic antagonist activity of azaprophen.

Carroll FI, Abraham P, Mascarella SW, Singh P, Moreland CG, Sankar SS, Kwon YW, Triggle DJ.
J Med Chem (1991) 34 : 1436 -1440
PubMed 2016720 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.71	9.71

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL287868	AZAPROPHEN	—	1	9.71

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL287868	AZAPROPHEN	Ki	=	0.196	nM	9.71