Assay Detail
Binding
CHEMBL744607
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Inhibition of Suc-Leu-Tyr-AMC binding to human mu-calpain from erythrocytes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.25 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407974 | — | — | 1 | 8.05 |
| CHEMBL423112 | — | — | 1 | 7.82 |
| CHEMBL69715 | — | — | 1 | 7.52 |
| CHEMBL73171 | — | — | 1 | 6.80 |
| CHEMBL307829 | — | — | 1 | 6.35 |
| CHEMBL70044 | — | — | 1 | 6.34 |
| CHEMBL409426 | — | — | 1 | 6.25 |
| CHEMBL304400 | — | — | 1 | 6.17 |
| CHEMBL69254 | — | — | 1 | 6.09 |
| CHEMBL69466 | — | — | 1 | 6.02 |
| CHEMBL303024 | — | — | 1 | 5.87 |
| CHEMBL306220 | — | — | 1 | 4.87 |
| CHEMBL68143 | — | — | 1 | 4.87 |
| CHEMBL69332 | — | — | 1 | 4.48 |
| CHEMBL68874 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407974 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL423112 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL69715 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL73171 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL307829 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL70044 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL409426 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL304400 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL69254 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL69466 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL303024 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL306220 | — | Ki | = | 13500.0 | nM | 4.87 |
| CHEMBL68143 | — | Ki | = | 13600.0 | nM | 4.87 |
| CHEMBL69332 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL68874 | — | Ki | = | 800000.0 | nM | - |